Cytotoxicity and antigenicity of antimicrobial synthesized peptides derived from the beetle Allomyrina dichotoma defensin in mice

Y Koyama, M Motobu, K Hikosaka, M Yamada… - International …, 2006 - Elsevier
… safety and antigenicity of these peptides for clinical practice. … cytotoxicity of these
synthesized peptides in mice macrophages and antigenicity by determining antibody titers in mice

Applications of antimicrobial peptides derived from the defensin of the rhinoceros beetle Allomyrina dichotoma

JUN ISHIBASHI - Juntendo Medical Journal, 2016 - jstage.jst.go.jp
… To test the antigenicity of the defensin-derived AMPs, they … The defensin-derived AMPs disrupt
the membrane in a mouse … We examined the cytotoxicity of the peptide-immobilized fibers …

[PDF][PDF] Therapeutic potential of antimicrobial peptides from insects

R Hull, R Katete, M Ntwasa - Biotechnol Mol Biol Rev, 2012 - academicjournals.org
… design to create novel synthetic peptides that show little or no cytotoxicity to non… antimicrobial
peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice

[HTML][HTML] Coleopteran antimicrobial peptides: prospects for clinical applications

M Ntwasa, A Goto, S Kurata - International journal of microbiology, 2012 - hindawi.com
… In addition to the wellcharacterized Drosophila and mouse … Cecropins are selectively
cytotoxic to cancer cells, preventing … focused on the defensins family of antimicrobial peptides,” …

Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect anti-bacterial peptide

H Saido-Sakanaka, J ISHIBASHI… - Biochemical …, 1999 - portlandpress.com
… of defensin by measuring the anti-bacterial activity of 64 overlapping 12-mer peptides derived
… have greater antibacterial activity than the original peptide, but show no cytotoxic activity. …

The medical potential of antimicrobial peptides from insects

M Tonk, A Vilcinskas - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
… of novel insect-derived AMPs, including potential cytotoxic, … sensitive to defensin from the
beetle Allomyrina dichotoma [54… against the mouse myeloma cell line P3-X63Ag8.653. Flow …

Selective cancer cell cytotoxicity of enantiomeric 9-mer peptides derived from beetle defensins depends on negatively charged phosphatidylserine on the cell surface

T Iwasaki, J Ishibashi, H Tanaka, M Sato, A Asaoka… - Peptides, 2009 - Elsevier
… even higher antimicrobial activity and similar antimicrobial … and d-peptide B showed no
cytotoxicity against normal mouse … l-peptide A, B and d-peptide B have poor antigenicity in mice

Development of short antimicrobial peptides derived from host defense peptides or by combinatorial libraries

KH Lee - Current pharmaceutical design, 2002 - ingentaconnect.com
… agents, low antimicrobial activity, induction of antigenicity, … (high antimicrobial activity and
low cytotoxicity for mammalian … insect defensin isolated from a beetle, Allomyrina dichotoma, …

Development of a bioactive fiber with immobilized synthetic peptides designed from the active site of a beetle defensin

M Nakamura, T Iwasaki, S Tokino, A Asaoka… - …, 2011 - ACS Publications
… These 9-mer peptides also show cytotoxicity against cancer cell lines, such as mouse myeloma,
… the design and development of antibacterial fibers on which antimicrobial peptides (ie, d-…

Effective control of Salmonella infections by employing combinations of recombinant antimicrobial human β-defensins hBD-1 and hBD-2

S Maiti, S Patro, S Purohit, S Jain… - Antimicrobial agents …, 2014 - Am Soc Microbiol
… We successfully produced two human β-defensins (hBD-1 … of infected mice after treatment
with hBD-1 and hBD-2 peptidesdefensins, such as porcine defensin, protegrin-1, and beetle